How asbestos to cancer
A team of researchers, led by Dr. Hanning Yang wood. Michael
Karbon, the Cancer Research Center at the University of Hawaii,
detected the relationship puzzle asbestos cancer. According to
statistics, more than 20 million people in the United States, and many
more around the world who are exposed to asbestos, the risk of
developing malignant mesothelioma, is intractable tumors do not respond
to different pharmaceutical treatments affects the membranes covering
the lungs and abdomen. It was found that inhalation of asbestos increases the risk of lung cancer among smokers.
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group, comprising participants from the universities of New York,
Chicago, webetrsbrg, and San Raffaele in Milan, Imperial London,
searching for an answer to a question that has baffled scientists over
the past 40 years: How can asbestos fibers, which kill cells, to cancer?
As is known to all the dead cell cannot grow or be a tumor.
They
found that asbestos kills cells by stimulating the process called
"programmed cell necrosis" from editing article (HMGB1) which in turn
stimulates tumor growth by type of inflammation causes the release of
certain mutagens. It also noted high levels of HMGB1 protein in plasma of patients who were exposed to asbestos. Thus,
the researchers concluded that they can target the HMGB1 protein to
prevent/treat malignant mesothelioma through some serological tests that
detect traces of asbestos in the blood. Through
intervention in inflammation mechanism caused by asbestos, HMGB1
protein, can reduce the risk of cancer in individuals exposed to
asbestos and reduce the rate of tumor growth in patients with malignant
mesothelioma.
In
an attempt to test this hypothesis, the team plans to conduct a
clinical trial in an isolated province of "kabadochia" which more than
50% of its population due to malignant mesothelioma. If the results are positive, it is likely that the experience is extended and applied in the United States.
In
fact, this research underlines the role of inflammation in various
types of cancer, it also suggests some new clinical tools to identify
individuals at risk, and reduction of tumor growth. The
researchers are planning to test a new hypothesis about the prevention
of malignant mesothelioma, as with colon cancer, aspirin or some abuse
drugs that stop inflammation.
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